We specialize in supporting client decisions in clinical trials and drug development in the field of immunology.  Through our vast collection of research and model components, we can apply pre-built model components to your project, build novel models, or license our technology for your model development and prediction needs.  All of our modeling projects center around developing the highest predictive power in the least amount of time, while meeting/exceeding client specifications.

Immunetrics has a suite of core modeling components that can be used independently for modeling analyses and/or combined with other components to support new disease states or conditions. These models can be customized to meet specific needs and are constantly evolving to support new research outcomes.

 

Immunology Physiology Critical Care

TH1/2/17/22

Tregs

CD8+ T cells

B cells

Monocytes/Macrophages

Neutrophils

Eosinophils

Mast cells

Endothelial cells

Epithelial cells

Keratinocytes

Cardiovascular system

Renal system

Pulmonary system

Skin

Joints

Inflammation

Coagulation/Bleeding

Trauma


Disease Models Key Outputs Supported Therapeutics

Rheumatoid Arthritis

Swollen/tender joint counts

ACR20/50/70

DAS28(3)-CRP/ESR

Low disease activity

Remission

Serum cytokines and biomarkers

Serum cell counts

MTX

5-ASA

Corticosteroids

JAK inhibitors

Anti-TNFs

Anti-IL6s

Anti-IL17s

Anti-T and B cell therapies

Anti-Survival therapies

Anti-Migration therapies

Psoriatic Arthritis / Psoriasis

Swollen/tender joint counts

ACR20/50/70

DAS28(3)-CRP/ESR

PASI 50/75/90/100

Serum cytokines and biomarkers

Serum cell counts

MTX

5-ASA

Corticosteroids

JAK inhibitors

Anti-TNFs

Anti-IL6s

Anti-IL17s

Anti-IL12/23

Anti-T and B cell therapies

Anti-Survival therapies

Anti-Migration therapies

Ulcerative Colitis

Mayo score

Response/Remission

Mucosal healing

Serum cytokines and biomarkers

MTX

5-ASA

Corticosteroids

Anti-TNFs

JAK inhibitors

S1P receptor antagonist

Immuno-oncology

 Melanoma

 Lymphoma

 Leukemia

RECIST criteria

Lesion size change

Serum cytokines and biomarkers

 Proprietary

Sepsis

Multi-Organ Dysfunction

Mean arterial pressure (MAP)

Central venous pressure (CVP)

Blood oxygen saturation (O2sat)

Breathing frequency

Tidal volume

Blood gases (PaO2, PaCO2)

Creatinine

Urinary output (UOP)

Coagulation proteins

Fluid therapy

Vasopressors

Ventilators

Diuretics

Dialysis

Antibiotics

Trauma

Cytokines

Immune cells

Coagulation proteins

Blood loss

Mean arterial pressure (MAP)

Blood oxygen saturation (O2sat)

Fluid therapies

Blood products

Ventilators