We specialize in supporting client decisions in clinical trials and drug development in the field of immunology. Through our vast collection of research and model components, we can apply pre-built model components to your project, build novel models, or license our technology for your model development and prediction needs. All of our modeling projects center around developing the highest predictive power in the least amount of time, while meeting/exceeding client specifications.
Immunetrics has a suite of core modeling components that can be used independently for modeling analyses and/or combined with other components to support new disease states or conditions. These models can be customized to meet specific needs and are constantly evolving to support new research outcomes.
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Immunology Physiology Critical Care TH1/2/17/22
Tregs
CD8+ T cells
B cells
Monocytes/Macrophages
Neutrophils
Eosinophils
Mast cells
Endothelial cells
Epithelial cells
Keratinocytes
Cardiovascular system
Renal system
Pulmonary system
Skin
Joints
Inflammation
Coagulation/Bleeding
Trauma
| Disease Models | Key Outputs | Supported Therapeutics |
|
Rheumatoid Arthritis
|
Swollen/tender joint counts
ACR20/50/70 DAS28(3)-CRP/ESR Low disease activity Remission Serum cytokines and biomarkers Serum cell counts |
MTX
5-ASA Corticosteroids JAK inhibitors Anti-TNFs Anti-IL6s Anti-IL17s Anti-T and B cell therapies Anti-Survival therapies Anti-Migration therapies |
|
Psoriatic Arthritis / Psoriasis |
Swollen/tender joint counts
ACR20/50/70 DAS28(3)-CRP/ESR PASI 50/75/90/100 Serum cytokines and biomarkers Serum cell counts |
MTX
5-ASA Corticosteroids JAK inhibitors Anti-TNFs Anti-IL6s Anti-IL17s Anti-IL12/23 Anti-T and B cell therapies Anti-Survival therapies Anti-Migration therapies |
|
Ulcerative Colitis |
Mayo score
Response/Remission Mucosal healing Serum cytokines and biomarkers |
MTX
5-ASA Corticosteroids Anti-TNFs JAK inhibitors S1P receptor antagonist |
| Immuno-oncology
Melanoma Lymphoma Leukemia |
RECIST criteria
Lesion size change Serum cytokines and biomarkers |
Proprietary |
|
Sepsis Multi-Organ Dysfunction
|
Mean arterial pressure (MAP)
Central venous pressure (CVP) Blood oxygen saturation (O2sat) Breathing frequency Tidal volume Blood gases (PaO2, PaCO2) Creatinine Urinary output (UOP) Coagulation proteins |
Fluid therapy
Vasopressors Ventilators Diuretics Dialysis Antibiotics |
|
Trauma |
Cytokines
Immune cells Coagulation proteins Blood loss Mean arterial pressure (MAP) Blood oxygen saturation (O2sat) |
Fluid therapies
Blood products Ventilators |