Validation:

The key for any model is the relationship between the model and the real-world process that is being modeled. Immunetrics has proven its ability to link its model to the inflammatory response through independent validation, including:

Publications:
In the following references, authorship by Immunetrics staff indicated in bold. Authorship by Immunetrics academic founders indicated in italics.

  • "The dynamics of acute inflammation", Kumar R, Clermont G, Vodovotz Y, and Chow CC. [Journal of Theoretical Biology 230, 145-155 (2004)]
  • "Mathematical and statistical modeling of acute inflammation," Clermont G, Chow CC, Constantine GM, Vodovotz Y, and Bartels J. [Proceedings of the International meeting of classification societies, 457-467, Springer, New York 2004]
  • "Mathematical models of the acute inflammatory response", Vodovotz Y, Clermont G, Chow CC, and An G. [Current Opinions in Critical Care 10, 383-390 (2004)]
  • "In silico design of clinical trials: A method coming of age", Clermont G, Bartels J, Kumar R, Constantine G, Vodovotz Y, Chow C. [Crit Care Med. 2004 Oct;32(10):2061-70]
  • "Mathematical simulations of sepsis and trauma", Vodovotz Y, Chow CC, Bartels J, Lagoa C, Kumar R, Day J, Rubin J, Ermentrout B, Riviere B, Yotov I, Constantine G, Billiar T, Fink M, Clermont G. [Proceedings of the 11th Congress of the European Shock Society 2005]
  • "The Acute Inflammatory Response in Diverse Shock States", Chow CC, Clermont G, Kumar R, Lagoa C, Tawadrous Z, Gallo D, Betten B, Bartels J, Constantine G, Fink MP, Billiar TR, Vodovotz Y. [Shock, 2005, Jul;24(1):74-84]
  • "Evidence-based Modeling of Critical Illness: An Initial Consensus from the Society for Complexity in Acute Illness", Vodovotz Y, Clermont G, Hunt CA, Lefering R, Bartels J, Seydel R, Hotchkiss J, Brause R, Ta'asan S, Neugebauer E, An G
  • "In Silico and In Vivo Approach to Elucidate the Inflammatory Complexity of CD14-deficient Mice " Prince JM, Levy RM, Bartels J, Baratt A, Kane JM, Lagoa C, Rubin J, Day J, Wei J, Fink MP, Goyert SM, Clermont G, Billiar TR, Vodovotz Y. [Mol Med. 2006 Jun 20]
  • "In Silico Models of Acute Inflammation in Animals", Vodovotz Y, Chow CC, Bartels J, Lagoa C, Prince JM, Levy RM, Kumar R, Day J, Rubin J, Constantine G, Billiar TR, Fink MP, Clermont G. [Shock, 2006, Sep;26(3):235-44]
  • "The role of Initial Trauma in the Host's Response to Injury and Hemorrhage: Insights from a Correlation Of Mathematical Simulations and Hepatic Transcriptomic Analysis" Lagoa C, Bartels J, Barratt A, Tseng G, Clermont G, Fink MP, Billiar TR, Vodovotz Y. [Accepted in Shock 2006]

Scientific Presentations:
These are only talks given by Immunetrics employees. The list by Immunetrics academic founders is too extensive.

  • ICCAI 2003: "In silico modeling of clinical trials to speed drug development", Chang S
  • ICCAI 2003: "Calibrating Models To Data: Automated Fitting Strategies", Bartels J
  • ICCAI 2004: "The Marketplace of Diseases Associated with Acute Inflammation", Chang S
  • ICCAI 2004: "Optimization Issues In Modeling", Bartels J
  • European Shock Society 2005: "Integrating Environmental Factors Into a Mathematical Model to Predict Mortality of Septic Patients", Chang S, Busche F, Vodovotz Y, Clermont G, Fink MP
  • ICCAI 2005: "Impact of in silico modeling on Biomarkers and Drug Discovery", Chang S, Busche F, Vodovotz Y, Clermont G, Fink MP
  • ICCAI 2005: "Identifying Candidate Model Clouds In Large Parameter Spaces" Bartels J, Constantine G
  • Shock 2005: "Identification and evaluation of biomarkers to guide drug therapy" Chang S, Busche F, Vodovotz Y, Clermont G, Fink MP
  • ICCAI 2006: "Mathematical models simulating clinical trial outcomes of sepsis patients treated with XigrisŪ" Chang S

Presented Posters

  • Shock 2006: In Silico and In Vivo Studies Modeling the Aged Acute Inflammatory Response Y. Vodovotz, R. Hoffman, A. Baratt, J. Wei, T. Billiar, G. Clermont, J. Bartels
  • Shock 2006: Presented poster "Mathematical Model Predicting Outcomes of Sepsis Patients Treated With XigrisŪ: ENHANCE Trial" S. Chang, A. Baratt, G. Clermont, J-M. Planquois, SB. Yan, M. Williams, W. Macias. Immunetrics, Inc, University of Pittsburgh, Eli Lilly and Company

Published Abstracts (not published as full papers):

  • "Simulating the roles of NO in septic shock" Vodovotz Y, Chow CC, Kumar R, Tawadrous Z, Betten B, Fink MP, Billiar TR, Clermont G. [Nitric Oxide 6:484 2002.
  • "Mathematical simulation of post-hemorrhage endotoxemia: Timing is critical for survival", Vodovotz Y, Lagoa C, Kumar R, Chow CC, Clermont G. [Shock 19:42 2003]
  • "A mathematical model of innate and adaptive immune responses to shock", Day J, Hoffman R, Kumar R, Chow C. C, Clermont G, Vodovotz Y. [J.Leukoc.Biol. Supplement:43 2003.]
  • "In silico and in vivo studies modeling the aged acute inflammatory response", Vodovotz Y, Hoffman R, Baratt A, Wei J, Lagoa C, Billiar TR, Clermont G, Bartels J. [Shock 25 Suppl. 1:39-40 2006]
  • "Integrating environmental factors into a mathematical model to predict mortality of septic patients", Chang S, Busche F, Vodovotz Y, Clermont G, Fink M. [Shock 23 Supplement 3:3 2005]
  • "Mathematical simulation of inflammation in porcine septic shock and ARDS", Nieman G, Bartels J, Wei J, Baratt A, Chang S, Puyana J, Carney D, Clermont G, DiRocco J, Vodovotz Y. [Shock 23 Supplement 3:3 2005]
  • "From mice to rats: inter-species prediction of the systemic inflammatory response using mathematical simulations" Lagoa C, Bartels J, Baratt A, Clermont G, Fink MP, Billiar TR, Vodovotz Y.
  • "Optimizing a therapeutic intervention: Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS)" Daun S, Federspiel WJ, DiLeo MV, Vodovotz Y, Chang S, Bartels J, Peng Z, Capponi V, Wagner W, Winchester J, Kellum JA

 

© 2007 Immunetrics