Immunetrics

Clinical Applications

Immunetrics models are always built on the most accepted biological mechanisms, mechanistically linked to the pathophysiology of a disease. Often, a customer's proprietary data exceeds what is available in the scientific literature. Our models can be customized to reflect this knowledge in applications for that customer. Once the biological framework is in place, we can incorporate variations in the physiology of individual patients and apply standard treatments based on patient condition. With this approach, we can simulate the results of nearly any interventional technology, whether it is part of the current standard of care or a novel therapy, and work closely with clinicians to optimize its use.

Therapeutic interventions

In our models, clinical interventions (fluids, vasopressors, etc.) are modeled as a virtual clinician, administering standard of care based on the state of a patient. Specific rules for administering treatments can be changed as required. This allows us to help clinicians refine existing treatment protocols such as early goal-directed therapy, or develop totally new therapeutic strategies. For example, we can use our modeling technology to apply closed-loop optimization to mechanical ventilation strategies, using real-time information about the patient's condition to continuously adjust ventilation parameters, improving the likelihood of a positive outcome.

Device development

The Immunetrics models can also be applied to the testing and optimization of novel medical technologies. We are currently involved in a collaborative project with the goal of developing a cytokine filtration therapy to be used in septic patients. Our model will be used to identify patient groups most likely to respond favorably to hemofiltration. Our models could also be used to significantly enhance the development of another example of an emerging technology: a bio-artificial liver device.